Cancer, being one of the leading causes of death worldwide, is causing a great burden in the overall healthcare industry. According to National Institutes of Health, the United States would be stormed by an estimated 1,735,350 number of new cancer cases together with 609,640 deaths from this deadly disease (1). Being one of the largest cancer centers in the world, The University of Texas MD Anderson Cancer Center in the US has more than seven decades of experience in eliminating cancer of any kind and is world-renowned for using and developing front-line diagnostic technology. JHMHP is honored to have an exclusive interview with the Chief Medical Executive (CME) of MD Anderson, Prof. Stephen M. Hahn who will share with us his daily routine as the CME, the essence and challenges of hospital management and how their center is striving to end cancer.